ADDRESSES
Head office
3 Kodesho Street, Off Mobolaji Bank Anthony Way, Ikeja, Lagos, Nigeria
REGIONAL OFFICE
2nd floor, Dbm plaza,
Plot 1381-1383, Aminu Kano, crescent, Wuse II, Abuja.
Nigeria
Work Hours
Monday to Friday: 8AM - 5PM
MPN PCR Panel Kit
MPN PCR Panel Kit
(now available with Interpretation Software)
The TRUPCR® MPN PCR Panel Kit is intended for the qualitative detection of JAK2-V617F, CALR, MPL W515K/L mutations and BCR-ABL1 translocation in Myeloproliferative neoplasms (MPNs) in peripheral blood samples using real-time PCR system.
Myeloproliferative neoplasms (MPN), previously called myeloproliferative disorders (MPD) are a group of diseases that are caused by an overproduction of one or more blood cell types (red cells, white cells or platelets) in the bone marrow. Myeloproliferative neoplasms (MPNs) are associated with dysregulation of tyrosine kinases, leading to abnormal downstream signaling pathways and increased cellular proliferation. Based on the presence or absence of the Philadelphia chromosome (BCR/ABL1 translocation), MPN are broadly grouped into two categories – Philadelphia positive (chronic myeloid leukemia) and Philadelphia negative (polycythemia vera, essential thrombocythemia and myelofibrosis). The Philadelphia chromosome-negative MPNs are characterized by mutations in various genes such as JAK2, MPL, CALR, PDGFRA, PDGFRB, FGFR1 and KIT. In addition, multiple chromosome abnormalities have been defined.
TRUPCR® MPN PCR Panel Kit is a Real-time PCR assay which is based on fluorescent signal generated from the presence of an oligonucleotide probe specific for target DNA sequence. This MPN Panel Test is a comprehensive kit which includes complete cDNA chemistry for RNA-based transcripts.
Key Features of the TRUPCR® MPN PCR Panel Kit:
- CE-IVD
- TRUPCR® MPN Panel Kit allows comprehensive detection of the most common diagnostic and prognostic markers for Myeloproliferative neoplasms (MPN).
- It detects the most common variants of transcripts in the fusion gene and the most common mutations in prognostics markers.
- The kit offers sensitivity to detect up to 10 copies of fusion transcripts BCR-ABL1 and up to 1% mutant allele in background of 99% wild-type allele for JAK 2, CALR and MPL genes.
- All the reagents for cDNA chemistry, PCR and real-time PCR are included in the kit.
- It is compatible with various Real Time & Conventional PCR instruments.
- Easy-to-use, rapid, reliable, comprehensive and cost-effective tests.
MPN interpretation software:
- CE-IVD
- TRUPCR® MPN Panel Kit allows comprehensive detection of
The RUO TRUPCR interpretation software simplifies and accelerate results analysis:
- Experiment Overview and Issue Highlighting: The software provides a comprehensive overview of experiments in a tabular format, automatically identifying and highlighting any issues encountered during the experiment.
- Automated Report Generation: Final reports are generated for all samples in the experiment, including amplification curves for visual verification, eliminating the need for manual checking.
- Improper Amplification Detection: The software uses machine learning algorithms to flag improper amplifications, which may result from incorrect threshold settings, ensuring accurate and automated data interpretation.
- It detects the most common variants of transcripts in the fusion gene and the most common mutations in prognostics markers.
- The kit offers sensitivity to detect up to 10 copies of fusion transcripts BCR-ABL1 and up to 1% mutant allele in background of 99% wild-type allele for JAK 2, CALR and MPL genes.
- All the reagents for cDNA chemistry, PCR and real-time PCR are included in the kit.
- It is compatible with various Real Time & Conventional PCR instruments.
- Easy-to-use, rapid, reliable, comprehensive and cost-effective tests.
