ADDRESSES
Head office
9 Balogun street
Off Kudirat Abiola way
Central Business District
Alausa,
Ikeja, Lagos
Nigeria.
REGIONAL OFFICE
2nd floor, Dbm plaza,
Plot 1381-1383, Aminu Kano, crescent, Wuse II, Abuja.
Nigeria
Work Hours
Monday to Friday: 8AM - 5PM
TITLE | CeliAK IgG LINE |
Product code | 4202 |
Indication | Celiac disease |
Description | Line immunoassay for the qualitative determination of IgG antibodies against deamidated gliadin and tissue transglutaminase in human serum |
Format | Test strips coated with highly purified deamidated gliadin and tissue transglutaminase |
Total incubation time | 80 min. |
Sample volume | 10 µL serum |
No. of determinations | 20 x 2 |
The CeliAK IgG LINE is a qualitative line immunoassay for the determination of IgG antibodies against deamidated gliadin (d-gliadin) and tissue transglutaminase (tTG) in human serum. The CeliAK IgG LINE is intended as an aid in the diagnosis of celiac disease in conjunction with other clinical and laboratory findings. The immunoassay is designed for manual professional in vitro diagnostic use.
Celiac disease or gluten-sensitivity is characterized by small intestinal damages leading to a so-called “flat” mucosa. Due to this extensive lesions, malabsorption occurs frequently accompanied with a depletion of key nutrients. The alcohol soluble fraction of gluten, gliadin, a substrate of tissue transglutaminase (tTG), represents a causative agent of celiac disease, by stimulating an inflammatory process in the small intestine.
Serological method of celiac disease diagnosis includes the detection of IgA and IgG antibodies to tissue transglutaminase and deamidated gliadin. IgA antibodies to tissue transglutaminase are considered to have the highest predictive value, thus patients suffering from IgA deficiency, a frequent concomitant disease in celiac patients, can be diagnosed using IgG type antibodies.
